Effect of cryotherapy and oral antihistamine in treatment of Alopesia Areata

Comparison of the effect of topical betamethasone, topical betamethasone with cryotherapy, topical betamethasone with cryotherapy and oral antihistamines on hair regrowth in alopecia areata patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210404050843N1

Enrollment

Registered

2021-05-14

Start date

2021-05-22

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alopecia Areata. Alopecia areata

Interventions

Intervention 1: Intervention group1: Treatment with betamethasone lotion 0.1%(made by Iran Najo company) daily for 12 weeks.The patient applies one to two drops of the drug (depending on the size of

Eligibility

Sex/Gender

All

Age

12 Years to No maximum

Inclusion criteria

Inclusion criteria: patient age above 12 years Do not take another tratment for alopecia areata for at least one month before enrollment in this trial Maximum of three hair loss patches in the scalp or beard area, each of which is a maximum of 3 by 3 cm. No nail involvement related to alopecia areata

Exclusion criteria

Exclusion criteria: Renal or liver dysfunction Patients with a history of allergy to antihistamines Pregnancy or Lactation Lack of patient cooperation to complete the treatment process Cold intolerance Cryoglobulinemia History of cold urticaria

Design outcomes

Secondary

Measure	Time frame
Patient satisfaction. Timepoint: Before the intervention (at the beginning of the study) and three months after the last treatment session. Method of measurement: Patient satisfaction rate by the questionnaire based on numerical selection from one to ten (0= no effect, 1,2= minor effect, 3,4= moderate effect, 5,6= good effect, 9,10= very good effect).	—

Primary

Measure	Time frame
Terminal hair regrowth percent. Timepoint: Before the intervention (at the beginning of the study )and three months after the last treatment session. Method of measurement: The evaluation is performed by the physician with the help of a questionnaire and based on the following scale:: Good response (more than 75% of terminal hair regrowth). Moderate response (between 50 and 75% of terminal hair regrowth). Poor response (between 25 to 50% of terminal hair regrowth) No response (less than 25% of terminal hair regrowth).	—

Measure

Time frame

Terminal hair regrowth percent. Timepoint: Before the intervention (at the beginning of the study )and three months after the last treatment session. Method of measurement: The evaluation is performed by the physician with the help of a questionnaire and based on the following scale:: Good response (more than 75% of terminal hair regrowth). Moderate response (between 50 and 75% of terminal hair regrowth). Poor response (between 25 to 50% of terminal hair regrowth) No response (less than 25% of terminal hair regrowth).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Sadat Mousavi

Esfahan University of Medical Sciences

marziehmusavi1994@gmail.com+98 31 3772 0390

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026