Gingival Recession. Gingival recession
Conditions
Interventions
Intervention 1: Intervention group: coronally advanced flap plus amniotic membrane seeded with whartons jelly mesenchymal stem for root coverage of single Millers class I and II gingival recessions. I
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged 18 or more Patients who have read, understood, and signed an informed consent form Patients who have been able and willing to follow study procedures and instructions Patients who have at least one tooth with buccal Miller class I or II recession type defects Recessions with = ? mm depth and = ?mm width in premolar, canine or incisor area, with probing depths =? mm and = ? mm keratinized tissue Treating only one tooth at each side as a test or control tooth in case of adjacent teeth with recession defects
Exclusion criteria
Exclusion criteria: ?ubjects who are participating in other clinical trials Subjects who have a history of cancer or human immunodeficiency virus Subjects who have an uncontrolled systemic disease with compromised healing potential (such as diabetes mellitus with a recent HbA?c > ?%) Using medications known to cause gingival enlargement and anticoagulants with International Normalized Ratio (INR) > ?.? and taking herapeutic doses of medications known to affect bone metabolism Those who fail to maintain good plaque control Teeth with extremely prominent root surfaces Teeth with Class V restorations extending to root surfaces Subjects who have any systemic acute infections in the areas intended for surgery Female subjects who are pregnant or lactating History of surgical periodontal treatment of the involved site Severe tooth malposition or open contacts Current or planned orthodontic treatment during the ?-month course of the study Molars; teeth with axial mobility; teeth with interproximal loss of attachment; teeth with crowns or veneers causing an undetectable CEJ Patients with a frenum and/or muscle attachment encroaching on marginal gingiva in the first ? weeks after frenectomy procedure History of weekly or more frequent use of smokeless chewing tobacco, pipe or cigar smoking and cigarette smoking within the previous ? months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recession depth: distance between CEJ and gingival zenith. Timepoint: at start point and 3 months after surgery. Method of measurement: measured with standard periodontal probe (williams probe).;Recession width: the width of the recession defect at the level of CEJ. Timepoint: at start point and 3 months after surgery. Method of measurement: measured with standard periodontal probe (williams probe).;Clinical attachment loss: the length from the CEJ to the depth of the pocket base. Timepoint: at start point and 3 months after surgery. Method of measurement: measured with standard periodontal probe(williams probe) in mesial,distal and buccal surfaces of tooth.;Probing depth: distance from gingival margin to the base of the sulcus or pocket. Timepoint: at start point and 3 months after surgery. Method of measurement: measured with standard periodontal probe(williams probe) at mesial, distal and buccal side of the tooth.;Keratinized tissue height: height of keratinized tissue from the free gingival margin to the mucogingival junction. Timepoint: at start point and 3 months after surgery. Method of measurement: measured with standard periodontal probe(williams probe).;Keratinized tissue thickness: the thickness of keratinized tissue measured from outer surface of buccal keratinized tissue to the buccal surface of the tooth. Timepoint: at start point and 3 months after surgery. Method of measurement: determined ?.?mm apically to the gingival margin on the central point of the buccal surface, using a number ?? endodontic file with an endodontic stop. | — |
Secondary
| Measure | Time frame |
|---|---|
| O´Leary plaque score: The presence of supra gingival plaque on all four tooth surfaces. Timepoint: at base time and 3 months after surgery. Method of measurement: The plaque is disclosed. The presence or absence of plaque is recorded in a simple chart. The plaque incidence in the oral cavity is expressed as an exact percentage.;Gingival index: The gingival index records gingival inflammation on facial, lingual, mesial and distal sites if teeth. Timepoint: at base time and 3 months after surgery. Method of measurement: Grade0: Normal gingiva Geade1: Mild inflammation Grade2: Moderate inflammation Grade3: Severe inflammation.;The subject’s perception of pain/discomfort: The amount of pain/discomfort that the patients experience because of exposed root surfaces and shows the amount of root hypersensitivity. Timepoint: at base time and 3 months after surgery. Method of measurement: visual analogue scale (?: no pain/discomfort ??:severe pain/discomfort). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Sabet
Shiraz University of Medical Sciences
Outcome results
None listed