Evaluation of the efficacy of Selenium supplementation therapy on the inflammatory markers oxidative stress and liver functional parameters

Evaluation of the efficacy of Selenium supplementation therapy on the inflammatory markers oxidative stress and liver functional parameters in thalassemia major and intermediate

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210326050772N1

Enrollment

Registered

2021-09-13

Start date

2021-09-22

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thalassemia major and intermedia. Beta thalassemia

Interventions

In these patients, in addition to routine treatments, they will take 200 micrograms of selenium tablets daily for 30 days..

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Willingness to participate in the study Having thalassemia major or intermedia Having healthy liver and kidney function

Exclusion criteria

Exclusion criteria: History of chemotherapy Take any supplements and vitamins at least two months before the study Diabetic patients Patients with acute and chronic infections Having any inflammatory disease

Design outcomes

Primary

Measure	Time frame
Inflammatory markers. Timepoint: Before the intervention and 30 days after the start of selenium consumption. Method of measurement: By measuring the inflammatory markers hCRP and ferritin.;Oxidative stress marker (Malondialdehyde). Timepoint: Before the intervention and 30 days after the start of selenium consumption. Method of measurement: By measuring the oxidative stress markers (Malondialdehyde).;Liver function parameters. Timepoint: Before the intervention and 30 days after the start of selenium consumption. Method of measurement: By measuring the liver function parameters (AST and ALT).	—

Measure

Time frame

Inflammatory markers. Timepoint: Before the intervention and 30 days after the start of selenium consumption. Method of measurement: By measuring the inflammatory markers hCRP and ferritin.;Oxidative stress marker (Malondialdehyde). Timepoint: Before the intervention and 30 days after the start of selenium consumption. Method of measurement: By measuring the oxidative stress markers (Malondialdehyde).;Liver function parameters. Timepoint: Before the intervention and 30 days after the start of selenium consumption. Method of measurement: By measuring the liver function parameters (AST and ALT).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Kambiz Davari

Zanjan University of Medical Sciences

Kddavari@zums.ac.ir+98 24 3313 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026