The effect of eliminating antibiotic treatment after appendectomy on surgical site infectionn

Efficacy of removing antibiotic therapy after appendectomy in surgical site infection in patients with imperforated appendicitis: A clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210319050743N1

Enrollment

232

Registered

2021-03-24

Start date

2021-04-04

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical site infection. Infection following a procedure

Interventions

Intervention 1: Intervention group: Receive a placebo (distilled water) one cc every 12 hours for 48 hours after surgery. Intervention 2: Control group: They receive one gram of ceftriaxone every 12 h

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with acute appendicitis referred to Ayatollah Mousavi Educational and Medical Center in Zanjan

Exclusion criteria

Exclusion criteria: Immunosuppression in patients undergoing appendectomy Diabetes AIDS Long-term use of corticosteroids Malnutrition Cancer Blood disease with leukocyte insufficiency

Design outcomes

Primary

Measure	Time frame
Purulent discharge from the wound. Timepoint: Clinical examination in The end of the first, second and fourth weeks After surgery. Method of measurement: History and clinical examination.;Redness and inflammation of the wound. Timepoint: Clinical examination in The end of the first, second and fourth weeks After surgery. Method of measurement: History and clinical examination.;Stomach ache. Timepoint: Clinical examination in The end of the first, second and fourth weeks After surgery. Method of measurement: History and clinical examination.;Fever. Timepoint: Clinical examination in The end of the first, second and fourth weeks After surgery. Method of measurement: History and clinical examination.;Presence of a mass at the surgical site. Timepoint: Clinical examination in The end of the first, second and fourth weeks After surgery. Method of measurement: History and clinical examination.	—

Measure

Time frame

Purulent discharge from the wound. Timepoint: Clinical examination in The end of the first, second and fourth weeks After surgery. Method of measurement: History and clinical examination.;Redness and inflammation of the wound. Timepoint: Clinical examination in The end of the first, second and fourth weeks After surgery. Method of measurement: History and clinical examination.;Stomach ache. Timepoint: Clinical examination in The end of the first, second and fourth weeks After surgery. Method of measurement: History and clinical examination.;Fever. Timepoint: Clinical examination in The end of the first, second and fourth weeks After surgery. Method of measurement: History and clinical examination.;Presence of a mass at the surgical site. Timepoint: Clinical examination in The end of the first, second and fourth weeks After surgery. Method of measurement: History and clinical examination.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammad Mohammadi Arbati

Zanjan University of Medical Sciences

mohammadarbati@zumc.ac.ir+98 24 3313 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026