?Effect of Sildenafil and estradiol valerate on increasing endometrial thickness

The effect of Sildenafil and estradiol valerate on increasing endometrial thickness before intra uterine insemination

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210313050688N1

Enrollment

100

Registered

2021-05-17

Start date

2021-05-22

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility due to nonimplantation of ovum. Female infertility of uterine origin

Interventions

Intervention 1: Control group: Patients of this group will receive An Estradiol valerate tablet every 12 hours from the 10th day of menstruation to the initiation of ovulation(10days) and also, they

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Patients with infertility due to a decreased endometrial thickness Age between 20 to 35 years old BMI lower than 30 kg per square meters

Exclusion criteria

Exclusion criteria: Women with congenital uterine abnormality or acquired deformity of uterine tube wich interferes with implantation Women with tubal infertility Women with contraindication to estrogen therapy (CVA or DVT history and benign hepatic diseases) Women wich have a male factor infertility (Aospermia , Teratospermia, ...)

Design outcomes

Primary

Measure	Time frame
Endometrial thickness. Timepoint: Based on the reported sonographic result 9 days after initiation of treatment. Method of measurement: Transvaginal Ultrasound.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Faranak Jalilvand

Ardabil University of Medical Sciences

f.jalilvand@arums.ac.ir+98 45 3324 8888

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026