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Effect of Henna vaginal suppository combined with antibiotic therapy in the treatment of cervicitis

The effect of Henna (Lawsonia inermis) vaginal suppository combined with antibiotic therapy in the treatment of cervicitis : A Randomized Triple-blind Clinical Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210312050686N1
Enrollment
92
Registered
2021-07-13
Start date
2021-08-06
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervicitis. N72

Interventions

Intervention 1: Intervention group: Cefixime 400 mg single dose, azithromycin 1 mg single dose and metronidazole 500 mg every 12 hours for 5 days and vaginal suppository of Henna oil based every night

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
21 Years to 50 Years

Inclusion criteria

Inclusion criteria: married non-menopausal women who confirme cervicitis through colposcopy and biopsy with symptoms such as refractory vaginal discharge, postcoital bleeding (PCB), abnormal uterine bleeding (AUB), abnormal Pap smear, or abnormal appearance of the cervix on examination with a speculum.

Exclusion criteria

Exclusion criteria: being pregnant lactating involved in any addiction observing herpes sores or genital warts on examination and/or HPV positive test dysplasia or cancer of cervix intake of herbal products or medications that influence cervicitis like antibiotics, immunosuppressive drugs or vaginal medications over 2 weeks before the commencement of the study history of allergies to Henna

Design outcomes

Primary

MeasureTime frame
Mean of ulcer size. Timepoint: Before the intervention, after completion of the intervention. Method of measurement: Clinical examination.

Secondary

MeasureTime frame
Vaginal discharges. Timepoint: Before the intervention, after completion of the intervention. Method of measurement: Visual Analogue Scale.;Irritation. Timepoint: Before intervention, after intervention. Method of measurement: Visual Analogue Scale.;Dyspareunia. Timepoint: Before intervention, after intervention. Method of measurement: Yes- no.;Postcoital bleeding. Timepoint: Before intervention, after intervention. Method of measurement: Yes- no.;Friability. Timepoint: Before intervention, after intervention. Method of measurement: Yes- no.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNaeeme Nabi Meybodi

Yazd University of Medical Sciences

dvc.research@ssu.ac.ir+98 35 3724 0171

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026