Polycystic ovary syndrome. Polycystic ovary syndrome
Conditions
Interventions
Intervention 1: Intervention group: N-acetylcystein administration (produced by Shimi Daru Company)1200 mg daily in two divided doses from the first day of the cycle for 4 weeks. Intervention 2: Inter
Sponsors
Zanjan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: aged 20-35 years infertile with polycystic ovary syndrome candidates for ovulation induction spouse with normal sperm analysis with normal hysterosalpingography without tubular pathology
Exclusion criteria
Exclusion criteria: Endocrine and endocrinological diseases such as thyroid disorders and abnormal prolactin Patients who used metformin and clomiphene more frequently in the previous cycle to induce ovulation Clomiphene resistant patients Pituitary or hypothalamic disorders characterized by low gonadotropin levels Drug allergy to metformin or N Acetyl Cystein Simple ovarian cyst Liver disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of follicles. Timepoint: Four weeks after the intervention. Method of measurement: Transvaginal ultrasound.;Endometrial thickness. Timepoint: Four weeks after the intervention. Method of measurement: Transvaginal ultrasound.;Size of follicles. Timepoint: Four weeks after the intervention. Method of measurement: Transvaginal ultrasound.;Frequency of intrauterine sac. Timepoint: Four weeks after the intervention. Method of measurement: Transvaginal ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive human chorionic gonadotropin (HCG). Timepoint: Four weeks after the intervention. Method of measurement: ELIZA test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMozhgan Ahmadi
Zanjan University of Medical Sciences
Outcome results
None listed