oligomenorrhea. Secondary Oligomenorrhoea
Conditions
Interventions
Intervention 1: Intervention group: After initial bleeding in both groups, saphenous vein phlebotomy means 30 cc of blood letting from saphenous vein on the medial side of the right ankle by Needle No
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
16 Years to 46 Years
Inclusion criteria
Inclusion criteria: Conscious consent to participate in the study, , , R/O of Cushing's syndrome and congenital adrenal hyperplasia. - - Menstruation delay that is: at least 60 days after their LMP or the number of cycles less than 7 cycles per year or more than 35 days in a cycle Known case of Poly cystic ovary syndrome According to the Rotterdam diagnostic criteria, there are two of the following three symptoms: i Abnormal menstrual cycles (oligomenorrhea, amenorrhea) ii Polycystic ovaries on ultrasound iii Clinical signs of hyperandrogenism (acne-hair loss) Or/ And hyperandrogenism biochemical signs Age 16-46 Body mass index (BMI) more or equal to 18
Exclusion criteria
Exclusion criteria: Any disease affecting the study variables (diabetes, liver, thyroid, cardiovascular, renal, gastrointestinal disorders, Cushing's syndrome, adrenal hyperplasia, androgen-secreting tumors, hyperprolactinemia) based on patients' past medical history History of thyroid disorders - history of anemia - History of coagulation disorders Use of anticoagulants, HTN or statins or antidiabetic drugs and insulin, oral contraceptive pills (OCP), glucocorticoids, anti-androgens, ovulation-inducing drugs Pregnancy and Breastfeeding FSH more or equal to 40 Use of any vitamin, mineral and hormonal supplements at least two months before the study Special diet regimen Smokers and alcohol users
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Menstruatin. Timepoint: At the beginning of the study (before the intervention), 1, 2 and 3 months later. Method of measurement: Pictorial blood loss assessment chart. | — |
Secondary
| Measure | Time frame |
|---|---|
| Determining and comparing the amount of anthropometric factors of patients including: body mass index. Timepoint: At the beginning of the study (before the intervention), 3 months later. Method of measurement: weighting.;Fasting blood insulin level. Timepoint: At the beginning and end of the study. Method of measurement: Blood biochemical test.;Blood LDL level. Timepoint: At the beginning and end of the study. Method of measurement: Blood biochemical test.;Blood DHEAS level. Timepoint: At the beginning and end of the study. Method of measurement: Blood biochemical test.;Bloood ferritin level. Timepoint: At the beginning and end of the study. Method of measurement: Blood biochemical test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Amir Mohammad Jaladat
Shiraz University of Medical Sciences
Outcome results
None listed