Evaluation of the effect of Barley extract in the treatment of chronic urticaria

Evaluation of the effect of Medicinal Ma-alshaeir( herbal product based on Iranian traditional medicine) in comparison with placebo on clinical symptoms of patients with Chronic Idiopathic Urticaria: A randomized triple-blind clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210309050643N1

Enrollment

Registered

2021-06-28

Start date

2021-06-22

Completion date

Unknown

Last updated

2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

urticaria. Urticaria

Interventions

Intervention 1: Intervention group: Herbal product based on barley seeds (Hordeum vulgare) in a dose of 15 grams in 2 doses for 4 weeks is prescribed. The herbal product contains an aqueous extract o

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with chronic spontaneous urticaria, aged 18 to 60 years do not have autoimmune disease or immunodeficiency wish to participate in the study

Exclusion criteria

Exclusion criteria: pregnancy Previous hypersensitivity to the drug or any of the compounds present in the herbal medicinal product

Design outcomes

Primary

Measure	Time frame
Detect the effect of barley extract on clinical symptoms of CSU patients. Timepoint: At the beginning of the intervention and 4 weeks after taking the drug. Method of measurement: International Urticaria Registration Questionnaire.	—

Secondary

Measure	Time frame
Urticaria clinical symptoms score. Timepoint: At the beginning of the intervention and 4 weeks later. Method of measurement: Urticaria Activity score Questionnaire.;Quality of life of chronic urticaria patients. Timepoint: At the beginning of the intervention and 4 weeks later. Method of measurement: score of Chronic Urticaria Quality of Life questionnaire.;Relapse of patients' clinical symptoms. Timepoint: At the beginning of the intervention and 4 weeks later. Method of measurement: Urticaria Control Test.	—

Measure

Time frame

Urticaria clinical symptoms score. Timepoint: At the beginning of the intervention and 4 weeks later. Method of measurement: Urticaria Activity score Questionnaire.;Quality of life of chronic urticaria patients. Timepoint: At the beginning of the intervention and 4 weeks later. Method of measurement: score of Chronic Urticaria Quality of Life questionnaire.;Relapse of patients' clinical symptoms. Timepoint: At the beginning of the intervention and 4 weeks later. Method of measurement: Urticaria Control Test.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahin Saeidinejat

Mashhad University of Medical Sciences

Saeedish1@mums.ac.ir0098513884892

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026