The effect of prolotherapy injection in the treatment of neuropathy

The effect of prolotherapy in perineural points and lower extremity acupoints on neuropathic pain in patients with neuropathy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210309050642N1

Enrollment

Registered

2021-03-30

Start date

2021-04-09

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuropathy. Polyneuropathy, unspecified

Interventions

Intervention 1: Intervention group 1: after sterilizing the injection site with betadine, injection of 5 cc of 5% dextrose solution construction of Pasteur Institute with 1 cc of 2% lidocaine solution

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Clinical signs of lower limb neuropathy in the last three months No response to conventional treatments Age 30-60 years Complete and sign the consent form

Exclusion criteria

Exclusion criteria: any tumor, infection, or skin lesion at the target site Pregnancy Bleeding disorders History of allergies to the drugs used

Design outcomes

Primary

Measure	Time frame
Douleur Neuropathique 4 questionnaire (DN4) score. Timepoint: For all patients, Douleur Neuropathique 4 questionnaire is filled out before injection and then in the first, second and eighth weeks after injection. Method of measurement: Completion of Douleur Neuropathique 4 Questionnaire.;Overall Neuropathy Limitations Scale (ONLS) score. Timepoint: For all patients, Overall Neuropathy Limitations Scale (ONLS) is filled out before injection and then in the first, second and eighth weeks after injection. Method of measurement: Completion of Overall Neuropathy Limitations Scale (ONLS) Questionnaire.	—

Measure

Time frame

Douleur Neuropathique 4 questionnaire (DN4) score. Timepoint: For all patients, Douleur Neuropathique 4 questionnaire is filled out before injection and then in the first, second and eighth weeks after injection. Method of measurement: Completion of Douleur Neuropathique 4 Questionnaire.;Overall Neuropathy Limitations Scale (ONLS) score. Timepoint: For all patients, Overall Neuropathy Limitations Scale (ONLS) is filled out before injection and then in the first, second and eighth weeks after injection. Method of measurement: Completion of Overall Neuropathy Limitations Scale (ONLS) Questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSharareh Roshanzamir

Shiraz University of Medical Sciences

sharareh.roshanzamir@gmail.com+98 71 3231 9040

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026