Investigating the effect of neoadjuvant chemotherapy on locally advanced rectal cancer

The Assessment of Efficacy for Neoadjuvant Chemotherapy with Modified FOLFOX6 compared to Chemoradiation for the Management of Locally Advanced Rectal Cancer: A Promising Therapeutic Approach

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210308050628N1

Enrollment

300

Registered

2023-12-08

Start date

2015-01-10

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Locally advanced Rectal cancers.

Interventions

Intervention group: ?????? ??????????? ????????????.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: age between 18-75 Rectal cancer(Adenocarcinoma) confirmed by pathology locally advanced tumors No distant metastasis Proper Performance status(PS: 0-1) proper blood condition proper renal function proper liver function

Exclusion criteria

Exclusion criteria: Recurrent rectal cancer previous pelvic radiotherapy history of other malignancy

Design outcomes

Primary

Measure	Time frame
Pathological complete response, down-staging of tumor invasion and lymph nodes involvement, 3-years disease free survival. Timepoint: Before treatment, During treatment, after treatment and 3 years follow up. Method of measurement: Pathology, Clinic and Paraclinic.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKamal Mohammadian

Hamedan University of Medical Sciences

km_282@yahoo.com+98 81 3838 0044

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 6, 2026