Metabolic syndrome. Metabolic syndrome
Conditions
Interventions
Intervention 1: Intervention group: Regular weight loss diet (daily limit of 500 kcal) and moderate carbohydrate restriction include 45-42% carbohydrates, 40-35% fat, and 17-15% protein. This diet sho
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Having metabolic syndrome based on The Adult Treatment Panel guidelines (ATP III) index Age 20 to 50 years Not being menopausal Body mass index greater than or equal to 25 Willingness to participate in the study
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding or deciding to get pregnant shortly Smoking even one cigarette or once using other tobacco such as hookah in the past week or repeated drug use History of the liver, kidney, thyroid, gastrointestinal diseases, diabetes, rheumatoid arthritis, lupus, severe infection, and trauma History of weight loss surgery Having a serious allergy to a particular medicine or food Follow a special diet for 3 months before the study Take any amount of supplements or food products fortified with fins or probiotics during the last 3 months Taking a variety of antibiotics per dose during the 3 months before enrollment Taking drugs that affect weight, appetite, blood pressure, or metabolism of carbohydrates and fats in the last 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal microbiome composition. Timepoint: Before the intervention and 3 months later. Method of measurement: Polymerase Chain Reaction (PCR) method.;Lipid profile (serum triglyceride, total serum cholesterol, low-density lipoprotein, high-density lipoprotein). Timepoint: Before the intervention and 3 months later. Method of measurement: Enzymatic method.;Waist circumference. Timepoint: Before the intervention and 3 months later. Method of measurement: Tape meter.;Fasting blood sugar. Timepoint: Before the intervention and 3 months later. Method of measurement: By glucose oxidase method and using commercial kits. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body weight. Timepoint: Before the intervention and 3 months later. Method of measurement: Scale.;Blood pressure. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: Sphygmomanometer.;Height. Timepoint: Before the intervention and 3 months later. Method of measurement: Meter. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Mohammad Mousavi
Tehran University of Medical Sciences
Outcome results
None listed