Knee osteoarthritic. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Cell therapy is a branch of modern regenerative medicine that uses autologous or allogeneic stem cells to treat many untreated diseases, including knee osteoarthritis. Stem cells are p
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Knee Osteoarthritis Based on American College of Rheumatology Criteria in Grades 1, 2, and 3: Lowrence - Kellergan Knee pain for at least six months Proper liver function (Bilirubin = 2.0 ?/?, AST/ALT = 100 IU/L) Proper renal function (Creatinine = 2.0 ?/?)
Exclusion criteria
Exclusion criteria: Any acute or chronic infection Pregnancy or decision to become pregnant Any intra-articular injection during the last three months Inflammatory joint disease or secondary osteoarthritis History of knee surgery Severe underlying disease such as uncontrolled diabetes, taking anticoagulants Daily use of opioid and non-opioid analgesics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain: The pain assessment scale is performed by the VAS test. In this questionnaire, which is filled in by the participant before the intervention and six months after the intervention, the least pain in the last trimester is zero and the number 10 is considered as the highest pain in the last trimester. Scores between zero and 10 for the amount of pain. Timepoint: Before intervention and 6 months after injection. Method of measurement: VAS questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain due to inflammation in the knee joint in the last 6 months. Timepoint: Before the intervention and 6 months later. Method of measurement: The VAS questionnaire is filled out by the patient for the amount of pain and the patient scores from 0 to 10 according to the amount of pain.;The range of motion of the knee joint from the extent position to 140 degrees is measured in both active and passive forms. Timepoint: Before intervention and 6 months after injection. Method of measurement: Goniometer.;Knee cartilage formation using MRI image. Timepoint: Before intervention and 6 months after injection. Method of measurement: MRI image of the knee in a supine position. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNaser amini
Iran University of Medical Sciences
Outcome results
None listed