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Comparison of the effect of tetracycline gel and gel containing mesoporous silica nanoparticles loaded with tetracycline on reducing microbial infection at the junction of implant and abutment

Comparison of the antibacterial effect of tetracycline gel and gel containing mesoporous silica nanoparticles loaded with tetracycline in the gingival sulcus fluid at the site of junction between the implant and the abutment

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210306050605N1
Enrollment
15
Registered
2021-04-20
Start date
2021-05-22
Completion date
Unknown
Last updated
2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

periodontitis. Post-osseointegration biological failure of dental implant

Interventions

Intervention 1: The first intervention group: first implant. Material used in the first intervention group:Tetracycline gel (with a water base containing one percent tetracycline and two percent gel)

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1- Having at least 3 implants in one jaw 2- Having a minimum age of 18 years 3- The depth of the probe around the implant is between 1-3 mm (height of the abutment heel inside the gingiva is maximum 3 mm) 4- Possibility of placing zirconia crown with upper gingival margin 5- At least 4 months have passed since the extraction of the replacement teeth.

Exclusion criteria

Exclusion criteria: 1- Pregnant and lactating women 2- Patients receiving antibiotics in the last 6 months 3- Having any systemic disease such as diabetes that affects oral health 4- Addiction to drugs, cigarettes or alcohol 5-History of allergy to tetracycline 6- Based on the flowchart of diagnosis of covid 19 in the levels of outpatient services for definite people with coronary heart disease and suspected of it (1. History of dry cough or chills or sore throat with shortness of breath with or without fever, which can be justified by another etiological factor 2. A patient with fever or respiratory symptoms (whatever the severity): A. Have a history of close contact with a probable / definite case of covid 19 within 14 days prior to the onset of symptoms. Health personnel) 7- Patients with bone thickness less than 5 mm in cbct and patients need graft and bone reconstruction 8- Presence of periodontal disease in other

Design outcomes

Primary

MeasureTime frame
The Measurement of the amount of bacteria after placing tetracycline gel and gel containing tetracycline-loaded nanoparticles in the implant for three times. Timepoint: 10 days 15 days 30 days after placing the sample. Method of measurement: Bacterial colony counting method.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFereydoon Parnia

Tabriz University of Medical Sciences

fereydoon.parnia@gmail.com+98 41 3335 3161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026