A Study of The Effect of Magnesium Sulfate on End-Tidal CO2 and Pain

A Study of the Effect of Intravenous Infusion of Magnesium Sulfate on the Level of Intraoperative End-Tidal CO2 and Postoperative Pain in Laparoscopic Cholecystectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210302050549N1

Enrollment

Registered

2021-03-27

Start date

2021-04-04

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End-Tidal CO2.

Interventions

Intervention 1: The intervention group receives 50 mg/kg of magnesium sulfate IV in 100 cc of normal saline 0.9%. Intervention 2: The control group receives 100cc of 0.9% normal saline.

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: ASA I-II patients 20 to 60 years of age

Exclusion criteria

Exclusion criteria: Drug allergy to magnesium sulfate Drug abuse Any neuromuscular disease (Ejection Fraction)EF < 40% Hypotension or Bradycardia by more than 20% during anesthesia Cardiac disease Hepatic or Renal failure Chronic respiratory failure Morbid obesity

Design outcomes

Primary

Measure	Time frame
End-Tidal CO2. Timepoint: During surgery. Method of measurement: With capnograph device.;Pain severity. Timepoint: After surgery during recovery, second, sixth, 12th and 24th hours. Method of measurement: Using the VAS (Visual Analogue Scale).	—

Secondary

Measure	Time frame
Blood Pressure. Timepoint: During Surgery. Method of measurement: Blood Pressure Cuff.;Heart Rate. Timepoint: During Surgery. Method of measurement: ECG (electrocardiogram) Monitoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahbube Akhundi Saleh Abad

Rafsanjan University of Medical Sciences

m.akhondi@rums.ac.ir+98 34 3428 8590

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026