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exosome therapy of osteoarthritis

Evaluation of the effect of injection of exosomes derived from mesenchymal cells on complications caused by osteoarthritis types 2 and 3

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210228050535N6
Enrollment
20
Registered
2025-06-24
Start date
2025-07-23
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis. Osteoarthritis, unspecified site

Interventions

Intervention 1: Intervention group: Patients in the intervention group are injected with 2 cc of exosomes (500 µg/mL) derived from menstrual blood mesenchymal stem cells Combination with hyaluronic ac

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 65 Years

Inclusion criteria

Inclusion criteria: Knee pain in the past 6 months Radiological confirmation of grade 2 or 3 knee osteoarthritis age over 30 years age under 65 years or 65

Exclusion criteria

Exclusion criteria: Any intra-articular knee injection within the past 3 months

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: The second and sixth months after exosome injection. Method of measurement: Questionnaire (WOMAC index).;Cartilage changes in the knee joint area. Timepoint: The second and sixth months after exosome injection. Method of measurement: Radiography.;Patellofemoral cartilage erosion; tibiofemoral cartilage erosion. Timepoint: The second and sixth months after exosome injection. Method of measurement: Radiography.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirali Khodashenas limoni

Mazandaran University of Medical Sciences

s.khodashenas@mazums.ac.ir+98 11 3354 3353

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026