The treatment of bone non-union by exosome therapy

The effectiveness of injection of mesenchymal stem cells' exosome in the treatment of bone non-union

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210228050535N4

Enrollment

Registered

2025-04-28

Start date

2025-05-05

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonunion of fracture. Nonunion of fracture

Interventions

Intervention group: In the operating room after prep and drape, under sterile conditions under C-arm, first aspiration of the area secretion for culture is performed and then exosome injection is perf

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with nonunion, long bone fractures after proper fixation Patients who have fracture site degradation visible on radiographs and tenderness at the fracture site, evidence of which persists 6 months after appropriate surgical fixation, indicating nonunion of the fracture. Patients with nonunion who have had more than one surgery and fixation

Exclusion criteria

Exclusion criteria: Unwillingness to participate in the study Use of corticosteroids History of immunodeficiency and diabetes from the study

Design outcomes

Primary

Measure	Time frame
Callus formation. Timepoint: 1 month after injection. Method of measurement: radiography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShabanali Khodashenas limoni

Mazandaran University of Medical Sciences

s.khodashenas@mazums.ac.ir+98 11 3354 3353

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026