Recurrent implantation failure.
Conditions
Interventions
Intervention 1: Intervention group: Fourty-eight hours before the transfer of frozen embryos 2 ml of autologous exosomes derived from menstrual blood mesenchymal cells with a total protein of 20 µg/µl
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Women with recurrent implantation failure who did not conceive after at least three embryo transfer cycles or after transferring at least ten good-quality embryos. Age between 20–40 years With Body Mass Index (BMI) under 30 kg/m2
Exclusion criteria
Exclusion criteria: Uterine abnormalities in hysteroscopy and hysterosalpingography Hematologic disorders Hormonal disorders Immunologic disorders Chromosomal abnormalities and genetic disorders in parents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chemical pregnancy rate. Timepoint: Two weeks after embryo transfer. Method of measurement: Measurement of B-HCG.;Clinical pregnancy rate. Timepoint: Five weeks after embryo transfer. Method of measurement: Sonography.;Abortion rate. Timepoint: During pregnancy. Method of measurement: Sonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Live birth rate. Timepoint: End of pregnancy. Method of measurement: Parturition.;Implantation rate. Timepoint: Six weeks after embryo transfer. Method of measurement: The number of gestational sacs divided by the number of transferred embryos.;Ongoing pregnancy. Timepoint: 20th week of pregnancy. Method of measurement: Sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShabanali Khodashenas
Mazandaran University of Medical Sciences
Outcome results
None listed