The effect of three-component mouthwash (nystatin, aluminum MGS and diphenhydramine), chamomile and mucosamine spray in the treatment of oral mucositis caused by chemotherapy

Evaluation of the effect of three compounds (nystatin, aluminum ammonia, and diphenhydramine), mouthwash, chamomile, and mucosamine spray in the treatment of chemotherapy-induced oral mucositis in malignancy in children with leukemia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210228050519N1

Enrollment

Registered

2021-12-27

Start date

2021-12-21

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severity of oral mucositis. ??????? ?????

Interventions

Intervention 1: Intervention group: Before starting chemotherapy, all subjects will be taught the correct way to observe oral hygiene, including brushing and flossing. All participants received a thre

Eligibility

Sex/Gender

All

Age

2 Years to 16 Years

Inclusion criteria

Inclusion criteria: Full consciousness Hospitalized in the oncology ward of Arak Children's Hospital No gum disease Lack of continuous use of painkillers and drugs Similar treatment protocol Minimum age 2 years and maximum 16 years Having oral mucosa (minimum score 1) No history of chamomile mouthwash and mucosamine spray

Exclusion criteria

Exclusion criteria: Improvement of oral mucosa before randomization

Design outcomes

Primary

Measure	Time frame
Severity of oral mucositis. Timepoint: On the first day (before the intervention), the seventh day and the fourteenth day. Method of measurement: Mucosal severity instrument with a scoring range of 0 to 4.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKhalil Namazi

Arak University of Medical Sciences

namazikhalil44@gmail.com+98 914 451 3811

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026