Comparison of the effects of melatonin, vitamin C and oral clonidine on the patient's hemodynamic response during anesthesia and afterwards to pain in septorhinoplasty surgery.

Comparison of the Effect of Oral Melatonin, Vitamin C and Clonidine on the Hemodynamic Response to Endotracheal Intubation, Anesthetic Requirements and Pain after Septorhinoplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210222050463N2

Enrollment

120

Registered

2023-06-26

Start date

2023-08-23

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Determining the effect of oral melatonin, vitamin C and clonidine on the hemodynamic response to laryngoscopy and endotracheal intubation, the need for anesthetics and pain after septorhinoplasty..

Interventions

Intervention group:.

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: The age group is 18-40 years Physical status I-II American Society of Anesthesiology Candidate for general anesthesia and endotracheal intubationCommunity Verified icon

Exclusion criteria

Exclusion criteria: Physical status III and above American Society of Anesthesiology History of cognitive and mental disorders (dementia, severe depression)Community Verified icon Patients who take anti-anxiety, sedative, anti-psychotic or anti-epileptic drugs. History of circadian rhythm disorders such as chronic fatigue syndrome and sleepiness History of chronic pain syndromes Body mass index more than 30 kg/m² History of difficult airway (Cormack Lehan grade [1] 2 or higher) or more than one intubation attemptCommunity Verified icon History of obstructive sleep apnea and severe asthmaCommunity Verified icon History of drug or alcohol abuse History of congestive heart failure, heart block or bradycardia History of liver or kidney failure History of allergic reaction to studied drugsCommunity Verified icon Patients who have difficulty communicating.Community Verified icon If the patient moves during laryngoscopy or intubation.Community Verified icon

Design outcomes

Primary

Measure	Time frame
Determining the effect of melatonin, vitamin C and oral clonidine on hemodynamic response. Timepoint: Continuously at baseline (T0), 120 minutes after study drug administration, upon entering the operating room (T1), after induction of anesthesia (T2), just before laryngoscopy and endotracheal intubation (T3), after Intubation at intervals of 1 minute (T4), 3 minutes (T5), 5 minutes (T6), 10 minutes (T7) and 15 minutes (T8). Method of measurement: Operating room monitoring device.	—

Measure

Time frame

Determining the effect of melatonin, vitamin C and oral clonidine on hemodynamic response. Timepoint: Continuously at baseline (T0), 120 minutes after study drug administration, upon entering the operating room (T1), after induction of anesthesia (T2), just before laryngoscopy and endotracheal intubation (T3), after Intubation at intervals of 1 minute (T4), 3 minutes (T5), 5 minutes (T6), 10 minutes (T7) and 15 minutes (T8). Method of measurement: Operating room monitoring device.

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Secondary

Measure	Time frame
Reducing the use of anesthetics and postoperative painCommunity Verified icon. Timepoint: During and after the operation. Method of measurement: VAS.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNoushin Sarvi Sarmeidani

Ahvaz University of Medical Sciences

nooshinsarvi9192@gmail.com+98 61 3390 6395

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026