Effects of Arctium Lappa root in individuals with type 2 diabetes

Effects of Arctium Lappa root on values of blood sugar, amylase, antioxidants, lipid ratios and insulin resistance in individuals with type 2 diabetes

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210222050455N1

Enrollment

Registered

2021-04-22

Start date

2021-04-04

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes. Diabetes mellitus due to underlying condition

Interventions

Intervention 1: Intervention group: One capsule Arctium Lappa root (460 mg) per day for 12 weeks. Intervention 2: Control group: One capsule placebo charcoal (460 mg) day for 12 weeks.

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: Diagnosis of type 2 diabetes over two years (FBS>125 ? 2hpp>200 ? HbA1c>6/5 ) No change in the dose of oral blood glucose lowering during testing Maintain physical activity and diet as usual during the test No liver, gastrointestinal and kidney diseases Lack of treatment with anticoagulants Do not take anti hypertensive drugs and diuretics No alcohol No smoking No allergies

Exclusion criteria

Exclusion criteria: People who receive vitamin supplements during the last three months People treated with insulin and other hormones People who are pregnant and breastfeeding

Design outcomes

Primary

Measure	Time frame
Fasting glucose. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Colorimetric.;Amylase. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Catalase. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;MDA. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Calorimetry.;Total antioxidant capacity (TAC). Timepoint: Before and after 12 weeks of intervention. Method of measurement: Calorimetry.;Insulin. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Eliza.;HbA1C. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Calorimetry.;Lipid profile. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Calorimetry.;Lipid ratios(Total Cholesterol/HDl-c and LDL-c/HDl-c). Timepoint: Before and after 12 weeks of intervention. Method of measurement: Formula.;HOMA-B. Timepoint: Before and after 12 weeks of intervention. Method of measurement: HOMA-IR model evaluation.	—

Measure

Time frame

Fasting glucose. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Colorimetric.;Amylase. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Catalase. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;MDA. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Calorimetry.;Total antioxidant capacity (TAC). Timepoint: Before and after 12 weeks of intervention. Method of measurement: Calorimetry.;Insulin. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Eliza.;HbA1C. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Calorimetry.;Lipid profile. Timepoint: Before and after 12 weeks of intervention. Method of measurement: Calorimetry.;Lipid ratios(Total Cholesterol/HDl-c and LDL-c/HDl-c). Timepoint: Before and after 12 weeks of intervention. Method of measurement: Formula.;HOMA-B. Timepoint: Before and after 12 weeks of intervention. Method of measurement: HOMA-IR model evaluation.

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Secondary

Measure	Time frame
Body mass index (BMI). Timepoint: Before and after 12 weeks of intervention. Method of measurement: weight/height.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoume Ghorbani

Arak University of Medical Sciences

M.ghorbani7133@gmail.com+98 86 3417 3501

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026