Assessment the effect of low level laser on the amount of matrix metalloproteinase-1.

Assessment the effect of low level laser(980nm) on the amount of matrix metalloproteinase-1 in gingival cervicular fluid in people undergoing fixed orthodontic treatment

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210221050435N3

Enrollment

Registered

2024-06-24

Start date

2024-06-30

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low level laser therapy.

Interventions

Intervention 1: Intervention group: In this group(includes two anterior teeth of the mandible whose side was chosen randomly), a Diode laser with a wavelength of 980 nm (Doctor Smile class 4 laser. Cl

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Individuals must be healthy and free of any periodontal and systemic diseases. Individuals must need fixed orthodontic treatment. Patients should not use any medicine. Patients must be willing and have informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: Non-attendance of patients on the scheduled date. Failure to oral hygiene care during treatment. The emergence of SARS-Cov-2, which prevents patients from visiting on time.

Design outcomes

Primary

Measure	Time frame
Amount of matrix metalloproteinase-1 in gingival cervicular fluid. Timepoint: Assessment of matrix metalloproteinase-1, one day and one week after laser therapy. Method of measurement: Absorbent papers are used for sampling. Patient samples are measured by MMP-1 ELISA kit ZellBio.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein agha Aghili

Yazd University of Medical Sciences

hosseinaghily@gmail.com+98 35 3625 5881

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026