Control of inflammatory process in patients with coronavirus affected by ZAX.1399.C03

Evaluation of anti-inflammatory effect of ZAX.1399.C03 on airways inflammation in patients with coronavirus in home care

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210218050404N1

Enrollment

Registered

2021-03-10

Start date

2021-06-21

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Incidence of inflammation due to the mechanism of COVID19. COVID-19

Interventions

Intervention 1: Intervention group: The medicinal composition of ZAX.1399.C03 in two daily doses, is consumed for 7 to 14 days. Intervention 2: Control group: The composition of popcorn flour is consu

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: COVID-19 is detected by PCR laboratory diagnostic kit Age over 18 years Both sexes (male and female) Having informed and written consent to participate in the study No history of any allergies No uncontrolled hypertension Do not take anticoagulants (aspirin, Plavix, warfarin) Not pregnant and breastfeeding No diabetes in the person

Exclusion criteria

Exclusion criteria: Disagreement of the responsible physician of the patient before randomization History of any allergies to drugs, various substances, food and ... History of liver and kidney disease Patient disagreement Inability of the patient to take the drug for any reason History of hypertension and heart disease

Design outcomes

Primary

Measure	Time frame
Inflammatory mediators of IL6. Timepoint: Before the intervention and seven days after the start of consumption of mango leaf extract. Method of measurement: ELISA test.;Dry cough. Timepoint: Daily. Method of measurement: Check list.;Sputum cough. Timepoint: Daily. Method of measurement: Check list.;Shortness of breath. Timepoint: Daily. Method of measurement: Check list.;Gastrointestinal manifestations. Timepoint: Daily. Method of measurement: Check list.;Fever. Timepoint: Daily. Method of measurement: Check list.;Muscle and joint pain. Timepoint: Daily. Method of measurement: Check list.;Fatigue and laziness. Timepoint: Daily. Method of measurement: Check list.;Shiver. Timepoint: Daily. Method of measurement: Check list.;Odor and taste activity. Timepoint: Daily. Method of measurement: Check list.	—

Measure

Time frame

Inflammatory mediators of IL6. Timepoint: Before the intervention and seven days after the start of consumption of mango leaf extract. Method of measurement: ELISA test.;Dry cough. Timepoint: Daily. Method of measurement: Check list.;Sputum cough. Timepoint: Daily. Method of measurement: Check list.;Shortness of breath. Timepoint: Daily. Method of measurement: Check list.;Gastrointestinal manifestations. Timepoint: Daily. Method of measurement: Check list.;Fever. Timepoint: Daily. Method of measurement: Check list.;Muscle and joint pain. Timepoint: Daily. Method of measurement: Check list.;Fatigue and laziness. Timepoint: Daily. Method of measurement: Check list.;Shiver. Timepoint: Daily. Method of measurement: Check list.;Odor and taste activity. Timepoint: Daily. Method of measurement: Check list.

—

Secondary

Measure	Time frame
Hospitalization in medical centers with normal activity. Timepoint: daily. Method of measurement: Check list.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmin Dakhili Ardestani

Fasa University of Medical Sciences

a.dakhili@fums.ac.ir+98 71 5335 0996

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026