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Effect of supplementation beetroot capsul with or without vitamin C on oxidative stress factors in patients with chronic coronary heart disease

Effect of supplementation beetroot capsul with or without vitamin C on serum fatty acids and oxidative stress factors in patients with chronic coronary heart disease. Double blind Randomized trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210217050393N3
Enrollment
90
Registered
2022-07-28
Start date
2022-08-23
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary heart disease. Atherosclerotic heart disease of native coronary artery

Interventions

Intervention 1: Intervention group1: 30 men and women with coronary heart disease received three 500 mg red beet capsules daily for 4 weeks each. Intervention 2: Intervention group 2 : 30 men and wome

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 30 to 65 years 2. Men and women with chronic coronary artery disease 3. Willingness to participate in research

Exclusion criteria

Exclusion criteria: 1. Do not consume more than 10% of capsules 2. The occurrence of any accident that affects a person's health 3. Having any acute illness during the study 4. Reluctance to continue cooperation in research 5. Body Mass Index more than 30 kg / m2 6. Acute heart accident in the past year 7.Taking any medicine outside the treatment protocol 8. Consumption of any herbal medicines 9. Allergy to red beet 10. Nitrate-containing drugs (such as nitroglycerin, isosorbide) 11. Using oral and injectable nutritional supplements for at least the last 4 months (vitamins D, C, E, calcium, magnesium, potassium and multivitamin-mineral, omega 3) 12. Disease (diabetes, kidney stones, gallstones, cancer and other chronic diseases)

Design outcomes

Primary

MeasureTime frame
Malondialdehyde. Timepoint: At the beginning of the study and 28 days after consume red beet capsules. Method of measurement: laboratory kit.;Myeloperoxidase. Timepoint: At the beginning of the study and 28 days after consume red beet capsules. Method of measurement: laboratory kit.;Total antioxidant capacity. Timepoint: At the beginning of the study and 28 days after consume red beet capsules. Method of measurement: laboratory kit.;Total Oxidant Status. Timepoint: At the beginning of the study and 28 days after consume red beet capsules. Method of measurement: laboratory kit.;Saturated fatty acids. Timepoint: At the beginning of the study and 28 days after consume red beet. Method of measurement: Gas Chromatography.;Polyunsaturated fatty acids. Timepoint: At the beginning of the study and 28 days after consume red beet. Method of measurement: Gas Chromatography.;Monounsaturated fatty acids. Timepoint: At the beginning of the study and 28 days after consume red beet. Method of measurement: Gas Chromatography.;Fatty acid indices. Timepoint: At the beginning of the study and 28 days after consume red beet. Method of measurement: Calculation through other fatty acids.

Secondary

MeasureTime frame
Waist circumference. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: tape measure.;Hip circumference. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: tape measure.;Neck circumference. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: tape measure.;Weight. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: Bioelectrical Impedance Analysis(BIA).;Fat mass. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: Bioelectrical Impedance Analysis(BIA).;Free fat mass. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: Bioelectrical Impedance Analysis(BIA).;Body Mass Index(BMI). Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: Bioelectrical Impedance Analysis(BIA).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Rezvani

Mashhad University of Medical Sciences

rezvanir@mums.ac.ir+98 51 3841 2081

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026