heart failure with reduced ejection fraction. Heart failure
Conditions
Interventions
Intervention 1: Intervention group: Patients will receive 250 mg Urolithin A BID for one month. Intervention 2: Control group: placebo pills BID for one month.
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
20 Years to 85 Years
Inclusion criteria
Inclusion criteria: Male Between the ages 25 to 85 years Left ventricular ejection fraction equal or lower than 40% New York Heart Association functional class equal or greater than II Received standard treatment of heart failure (including Angiotensin-converting enzyme 2 inhibitors or Angiotensin II receptor inhibitors and beta blockers) for at least 2 weeks Signed informed consent
Exclusion criteria
Exclusion criteria: History of myocardial infarction during the 8 past weeks History of any malignant disease Renal failure (eGFR lower than 20 ml/1.73 m2/min) hepatic disorder (aminotransferase > 2x upper limit of normal) Extensive heart surgery or angioplasty during the past 30 days Allergy and/or hypersensitivity to specific drugs or substances related to drug used in this clinical trial uncontrolled high blood pressure (Systolic blood pressure higher than 180 mmHg and diastolic blood pressure higher than 100 mmHg)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction. Timepoint: Before and 1 month after intervention. Method of measurement: Echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| N-terminal pro b-type natriuretic peptide (NTproBNP). Timepoint: Before and 1 month after intervention. Method of measurement: Evaluation in serum by using a commercially available kit.;NYHA functional class. Timepoint: Before and 1 month after intervention. Method of measurement: Evaluation of symptoms by clinician.;Serum cardiac troponin. Timepoint: Before and 1 month after intervention. Method of measurement: Evaluation in serum by using a commercially available kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMilad Iranshahi
Mashhad University of Medical Sciences
Outcome results
None listed