High grade glioma. Malignant neoplasm of brain
Conditions
Interventions
Intervention 1: Intervention group: intervention group will undergo radiotherapy to the lesion (46 gray dose in 23 fractions to a margin of 1 cm to the high signal region in the , T2/ FLAIR sequences
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Newly diagnosed glioblastoma multiform patients Newly diagnosed anaplastic astrocytoma patients Newly diagnosed oligodendroglioma patients Confirmed diagnosis based on pathologic evaluation Karnofsky performance index more than 70%
Exclusion criteria
Exclusion criteria: Uncontrolled diabetes Uncontrolled high blood pressure Impossibility of surgery and tissue sampling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival. Timepoint: At the beginning of the study and then every 3 months in the first year and every 6 months in the following years. Method of measurement: Physical exam and MRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival. Timepoint: Every 3 month in the first year and every 6 month in subsequent years. Method of measurement: Physical exam and MRI.;Pattern of failure. Timepoint: Every 3 month in the first year and every 6 month in subsequent years. Method of measurement: Physical exam and MRI. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParisa Rabiei
Mashhad University of Medical Sciences
Outcome results
None listed