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Comparing the effectiveness of Kaletra/Hydroxychloroquine and Atazanavir/Dolutegravir/Hydroxychloroquine treatment regiments in COVID-19 treatment

Comparing the effectiveness of Lopinavir/Ritonavir/Hydroxychloroquine and Atazanavir/Ritonavir/Dolutegravir/Hydroxychloroquine treatment regiments in moderate to severe COVID-19 patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210214050350N1
Enrollment
60
Registered
2021-02-22
Start date
2021-02-14
Completion date
Unknown
Last updated
2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. covid-19 virus identified

Interventions

Intervention 1: Intervention group: This group will receive Atazanavir (300 mg)\ Ritonavir (100 mg) twice a day - Dolutegravir (500 mg) once a day and Hydroxychloroquine (400 mg BD for the first day a

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Having three or more of the following conditions:(1) Cough (2) weakness (3) fever of =38.5°C (4) Intense fatigue (5) myalgia (6) sore throat (7) Dyspnea (8) Low appetite/Diarrhea/nausea (9) Decreased awareness Or having one or more of the following disease characteristics: (1) Oxygen saturation value of less than 93% (2) disease confirmation based on chest imaging results (3) A respiratory rate greater than 24 breaths per minute

Exclusion criteria

Exclusion criteria: Negative COVID-19 specific PCR test result Patients that are well enough to not need hospitalization

Design outcomes

Primary

MeasureTime frame
Death. Timepoint: During treatment. Method of measurement: Clinical.;ICU admission. Timepoint: During treatment. Method of measurement: Clinical.;Intubation. Timepoint: During treatment. Method of measurement: Clinical.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeed Kalantari

Iran University of Medical Sciences

sara.minaeian@gmail.com+98 21 6635 2306

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026