Polycystic ovary syndrome. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Control group: 20 PCOS patients received oral rehydration solution (ORS) at a dose of 25 mg once a day orally for 8 weeks. This solution contains water, sugar, and salt (electrolytes),
Sponsors
Arak University
Eligibility
Sex/Gender
Female
Age
25 Years to 40 Years
Inclusion criteria
Inclusion criteria: Menstrual disorders including oligomenorrhea or anovulation Hirsutism Infertility ultrasound findings of enlarged ovaries and multiple follicles measuring 2-10 mm, increased LH/FSH ratio high AMH levels hyperandrogenism normal thyroid function prolactin levels normal sperm analysis of the partner
Exclusion criteria
Exclusion criteria: Resistance to metformin or empagliflozin or using effective drugs in the metabolism of carbohydrates Hyperprolactinemia Cushing syndrome Congenital adrenal hyperplasia Thyroid gland disorder Severe liver or kidney diseases Abnormal sperm parameters in one's spouse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of biochemical factors. Timepoint: Before taking the drug and 8 weeks after starting to take the drug. Method of measurement: Biochemical kits using ELISA method.;Measurement of hormone levels. Timepoint: Before taking the drug and 8 weeks after starting to take the drug. Method of measurement: Hormonal kits using the ELISA method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Examination of oocyte quality. Timepoint: After completing the intervention. Method of measurement: Examining the morphology of ovules and embryos using an inverted microscope.;Molecular studies. Timepoint: 8 weeks after starting the medication. Method of measurement: Use of real time polymerase chain reaction kit and device (Real time PCR). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSonieshargh Shima
Arak University
Outcome results
None listed