Lichen planopilaris. Lichen planopilaris
Conditions
Interventions
Intervention group:The intervention groups in addition to the control treatment will be treated with pentoxifylline 400 mg twice daily and N-acetylcysteine ??600 mg twice daily, respectively. LPPAI in
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 70 Years
Inclusion criteria
Inclusion criteria: Informed consent Do not have serious internal disease. Aged between 15-70 No history of serious gastrointestinal problems. There is no accompanying disease on the treatment site The initial general Lab data of the patient do not show a serious problem
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To facilitate statistical comparison of the study results, the lichen planopilaris activity index scoring system (LPPAI) introduced by Chiang in 2010 will be used. In this system, 8 signs and symptoms of the disease are scored, including Itching, burning, pain, erythema, pre-follicular erythema, pre-follicular scale, anagen pull test and disease spreading.each criteria will be scored from 0 to 3:Thus, 0:lack of sign/symptom, 1:the mild sign/symptom, 2:the moderate sign/symptom and 3:the severe sign/symptom. In agagen pull test, zero score shows the result is negative and it is positive when the score is one. In spreading score, zero score shows no spreading, 1:moderate spreading and 2: sever spreading. The total score according to the following formula will be 0 to 10: LPPAI (0 to 10) = (itching + burning + pain) / 3 + (scalp erythema + pre-follicular erythema + pre-follicular shell) / 3 + 2.5 (anagen pull test)+1/5(spreading/ 2).The tolerability of the treatment will be measured by asking the patients (yes / no) and the satisfaction of the treatment will be evaluated by a Likert scoring. Patients will be asked about the possible side effects of the drugs used in each appointment session (basic visit, second and fourth month). Timepoint: At the beginning of the study (before the intervention), 2 and 4 months after the intervention. Method of measurement: Lichen planopilaris activity index score: A questionnaire for assessing the severity of lichen planoplaris disease, which was developed and reported in 2010 by Chiang. Complications: Patient response based on Likert scale. Tolerance: Patient response based on Likert scale. Satisfaction: Patient response based on Likert scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Ahmadi Kahjoogh
Iran University of Medical Sciences
Outcome results
None listed