Repeated implantation failure. Complication associated with artificial fertilization, unspecified
Conditions
Interventions
Intervention 1: Intervention group: 48 hours before the transfer of frozen embryos according to the figures regarding the number of injected particles. For SAFATEY work, first particles/unit 1010×1 ex
Sponsors
Iranian academic center for education culture and research
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Women with recurrent implantation failure who have not become pregnant after at least three embryo transfer cycles or after transferring at least ten good-quality embryos Age between 20 - 40 Body mass index below 30 kg/m2
Exclusion criteria
Exclusion criteria: Abnormal uterine shape on hysterosalpingography or hysteroscopyChromosomal abnormalities and genetic disorders in parents Uterine abnormality Intrauterine adhesions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of reactivity (non-reactor) (absence of fever, nausea, bleeding, pain, and signs of allergic reaction) of exosome injection. Timepoint: Before the start of the intervention, two hours, two weeks, 3 months and 6 months after exosome injection. Method of measurement: Clinical evaluation.;Implantation. Timepoint: 4 weeks after embryo transfer. Method of measurement: Vaginal ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Abortion rate. Timepoint: During pregnancy. Method of measurement: Ultrasound.;Endometrial thickness and quality. Timepoint: 48 hours after injection. Method of measurement: Vaginal ultrasound.;Pregnancy. Timepoint: 4 weeks after embryo transfer. Method of measurement: Vaginal ultrasound. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAtefeh Verdi
Iranian academic center for education culture and research
Outcome results
None listed