Modification of Complications Caused by Polycystic Ovary Syndrome by Nano Curcumin Drug and HIIT Exercise in Women Undergoing ICSI Treatment

Effects of High Intensity Interval Training(HIIT) with Nano Curcumin Supplementation on MDA,SOD,GPX,TAC, LH,FSH,TT and Oocytes Maturation , Embryos Quality in Patients with PCOs Undergoing ICSI treatment. a Randomized Placebo-Controlled Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210207050279N1

Enrollment

Registered

2024-01-10

Start date

2023-12-31

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention Group: Curcumin Nano Micelle Capsule (80 mg Daily for 12 Weeks) and Metformin (500 mg Daily for 12 weeks). Intervention 2: Intervention group: HIIT ?Exercise (Three Sessio

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Period Disorders Hirsutism Infertility Increased LH/FSH ratio Ultrasound View in the form of Enlarged Ovaries Having Numerous Follicles with a Size of 2-10 mm The Normality of Sperm Analysis Normal Thyroid Function No Endometriosis Normal Prolactin Level Normal Hysterosalpingography

Exclusion criteria

Exclusion criteria: Infertility Factors other than Ovulation Male factor infertility Pelvic Organ Injuries Congenital Adrenal Hyperplasia Thyroid Dysfunction Cushing Syndrome Severe Liver or Kidney Diseases Active Gastric Ulcer Drug Sensitivity Intolerance of Exercise

Design outcomes

Primary

Measure	Time frame
Regulation of Sex Hormones. Timepoint: Before Taking the Drug and 12 weeks After Starting to Take the Drug. Method of measurement: Elisa Kit.;Stress Oxidative Level. Timepoint: Before Taking the Drug and 12 weeks After Starting to Take the Drug. Method of measurement: Laboratory Kits.;Oocyte and Embryo Quality. Timepoint: After Completing the Intervention. Method of measurement: Shape and Morphology.	—

Measure

Time frame

Regulation of Sex Hormones. Timepoint: Before Taking the Drug and 12 weeks After Starting to Take the Drug. Method of measurement: Elisa Kit.;Stress Oxidative Level. Timepoint: Before Taking the Drug and 12 weeks After Starting to Take the Drug. Method of measurement: Laboratory Kits.;Oocyte and Embryo Quality. Timepoint: After Completing the Intervention. Method of measurement: Shape and Morphology.

—

Secondary

Measure	Time frame
Pregnancy Rate. Timepoint: 2 Weeks After Embryo Transfer. Method of measurement: Laboratory kits.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElham Asa

Iranian academic center for education culture and research

asa.elham@gmail.com+98 25 3339 8378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026