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The effect of Drug therapy on the treatment of overactive Bladder in Multiple Sclerosis, The effect of Physiotherapy on the treatment of overactive Bladder in Multiple Sclerosis

Comprasion of efficacy of Drug therapy(Solifenacin Succinate) and physiotherapy(Stimulation of Posterior Tibialis Nerve) on treatment of overactive Bladder and quality of life in Patients with Multiple Sclerosis

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210207050277N1
Enrollment
70
Registered
2021-03-13
Start date
2021-03-21
Completion date
Unknown
Last updated
2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Multiple sclerosis. Condition 2: Overactive Bladder Disorder. Multiple sclerosis Other disorders of bladder

Interventions

Intervention 1: First Intervention group: Drug treatment The oral tablet of Sulifenacin succinate 5 mg under the brand name Vsol (Abidi Company) is used. It was developed in 2004 and is one of the ant

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: No infection in the Urinary tract Have a minimum score of 3 in the Actionable questionnaire to confirm Neurogenic overactive Bladder Urinary incontinence that may or may not be accompanied by urgent Urinary incontinence At least 1 month has passed since the onset of symptoms of overactiveBladder disorder At least one month has passed since the last MS attack EDSS scale (severity of degree of disability) 1 to 5.5

Exclusion criteria

Exclusion criteria: Pregnant Women and those who want to get Pregnant within the next year Allergy to the Drug Sulifenacin such as Angioedema Heart problems (such as Heart failure) Have a history of surgery to treat Urinary incontinence or other Urinary tract surgeries Having stress Urinary incontinence Having Diabetes and Neurological diseases such as Parkinson's History of Anticholinergic Drug therapy for the treatment of overactive Bladder during the last month History of Electrotherapy treatment in the lower limbs and lower back and history of Pelvic floor Muscle Physiotherapy during a recent month Having a Heart Pacemaker and a Prosthesis in the leg Having a lesion at the site of Electrical stimulation of the Posterior Tibial Nerve

Design outcomes

Primary

MeasureTime frame
Severity of Urinary Symptoms. Timepoint: Evaluation of urinary symptoms at the beginning of the study (before the intervention) and 4, 8 and 12 weeks after the intervention. Method of measurement: International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB).;Urinary Incontinence. Timepoint: Evaluation of urinary incontinence at the beginning of the study (before the intervention) and 4, 8 and 12 weeks after the intervention. Method of measurement: International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form(ICIQ-UI SF).

Secondary

MeasureTime frame
Quality Of Life. Timepoint: Evaluation of Quality of life at the beginning of the study (before the intervention) and 4, 8 and 12 weeks after the intervention. Method of measurement: Multiple Sclerosis Quality of Life Questionnaire (MSQOL-54).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Jafari

Ahvaz University of Medical Sciences

dr.mohammadjafari1368@gmail.com+98 61 3377 3012

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026