The effect of olfactory training and vitamin A in the olfactory loss of patients with covid-19.

A comparative study of the effect of olfactory training and vitamin A in the olfactory loss of patients with covid-19.

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210205050247N1

Enrollment

Registered

2021-02-13

Start date

2021-02-18

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

olfactory loss. Other disturbances of smell and taste

Interventions

Intervention 1: Intervention group: This group will be treated with respiratory physiotherapy or olfactory rehabilitation for 12 weeks. Intervention 2: Intervention group: The second group will be tre

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age between 20 and 65 No underlying disease including: hypertension, hypo and hyperthyroidism, seizures, diabetes, asthma, Bell's palsy Continuation of olfactory reduction for more than two weeks

Exclusion criteria

Exclusion criteria: Patient dissatisfaction Prolonged exposure to some chemicals agents (detergents) History of head trauma History of sinus surgery or septorhinoplasty, rhinoplasty, turbinectomy and radiation therapy Having neurodegenerative disease (Alzheimer's, Parkinson, MS, epilepsy, seizures) Having mental disorders (schizophrenia and depression) Having neuropsychiatric disorders (autism, Asperger's, lack of concentration and hyperactivity) History of repeated use of the following drugs:Metronidazole, benzocaine, clofibrate, amphotericin B, ampicillin, allopurinol, captopril, baclofen, codeine, carbamazepine and amphetamines.

Design outcomes

Primary

Measure	Time frame
Smell Identification. Timepoint: The olfactory test is performed for 12 weeks, twice a day, each time inhaling each odor for 10 seconds. Method of measurement: Aromatic kit that includes 4 main scents (eucalyptus, lemon, rose and Dianthus).	—

Secondary

Measure	Time frame
Clinical recovery. Timepoint: For 12 weeks. Method of measurement: Clinical Global Impression Severity (CGI-S) Scale.;Olfactory Dysfunction Outcomes Rating (ODOR). Timepoint: For 12 weeks. Method of measurement: Pre-test and post-test questionnaires will be filled in all three groups.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Naderi

Bagheiat-allah University of Medical Sciences

dr.abolfazl.taheri@gmail.com+98 21 8670 5503

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026