Covid 19. COVID-19, virus identified
Conditions
Interventions
Intervention 1: Intervention group: In this group, patients (n=30) will receive 15 mg crocin tablet (Krocina™, made by Sami Saz Company) , twice a day, for 14 days. Intervention 2: Control group: In t
Sponsors
National Institute for Medical Research Development (NIMAD)
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed cases of Covid-19 2. Patients admitted to hospital Covid-19 general wards 3. Being 20-60 years old, of either sex. 4. Ability to sallow oral medication. 5. Patients without immunodeficiency and gastrointestinal disorders 6. Not being pregnant/breast feeding
Exclusion criteria
Exclusion criteria: 1. Being allergic to saffron/crocin 2. Inability to swallow oral medication during admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cell blood count (CBC). Timepoint: on days 0, 7 and 14. Method of measurement: CBC will be measured by auto analyzer. Differential cell counts will be performed in stained peripheral blood smear (Wright-Giemsa) under light microscope.;Serum C-reactive protein (CRP) level. Timepoint: on days 0, 7 and 14. Method of measurement: CRP serum level will be measured using standard ELISA kits.;TNF-a serum level. Timepoint: on days 0, 7 and 14. Method of measurement: TNF-a serum level will be measured using standard ELISA kits.;LDH serum level. Timepoint: on days 0, 7 and 14. Method of measurement: LDH serum level will be measured using standard ELISA kits.;Erythrocyte sedimentation rate (ESR). Timepoint: on days 0, 7 and 14. Method of measurement: Sedimentation Analyzer. | — |
Secondary
| Measure | Time frame |
|---|---|
| A. Clinical signs and symptoms: fever, cough, dyspnea, myalgia, chill, headache, respiratory rate, weakness, chest pain, nausea, vomiting, gastro-intestinal manifestations, O2 saturation. Timepoint: On days 0 and 14. Method of measurement: Clinical signs and symptoms will be recorded using the checklist.;Lung involvement. Timepoint: On days 0 and 14. Method of measurement: Lung radiography assessment will be performed by lung high-resolution computed tomography (HRCT). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRamin Rezaee
Mashhad University of Medical Sciences
Outcome results
None listed