The effect of Cassia fistula syrup on constipation

The effect of Cassia fistula syrup on quality of life in patients undergoing hemodialysis with constipation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210202050229N1

Enrollment

Registered

2021-08-02

Start date

2021-07-23

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

quality of life.

Interventions

Intervention 1: Intervention group: The drug group is given 10% Cassia fistula syrup (each 1 ml containing one tenth of a gram of dried pulp of Cassia fistula fruit) in the amount of 10 ml twice dai

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age 18 years and above Dialysis adequacy index above 1/2 At least 3 months have passed since the start of hemodialysis Having at least two of the criteria of Rome-3

Exclusion criteria

Exclusion criteria: Sensitivity to plant compounds, especially Cassia fistula History of active infection in the last month Absence of gastrointestinal diseases including irritable bowel syndrome, secondary constipation or neurological diseases (Parkinson's, depression, etc.) Non-neurological diseases (hypothyroidism, hypokalemia, etc.) History of any gastrointestinal surgery

Design outcomes

Primary

Measure	Time frame
Quality of Life Score in the Patient Assessment of Constipation Quality of Life (PAC-QOL) questionnaire. Timepoint: Measurement of quality of life before the intervention and 30 days after the start of Cassia fistula syrup. Method of measurement: Patient Assessment of Constipation Quality of Life (PAC-QOL) questionnaire.;Constipation score in the Constipation Assessment Scale (CAS). Timepoint: Measurement of Constipation before the intervention and 30 days after the start of Cassia fistula syrup. Method of measurement: Constipation Assessment Scale (CAS).;Frequency and frequency of defecation. Timepoint: Measurement of the frequency of defecation on a daily basis the start of Cassia fistula syrup. Method of measurement: Make a note in the checklist.;Stool consistency in the Bristol stool scale. Timepoint: Measurement of the stool consistency after each bowel movement after starting Cassia fistula syrup. Method of measurement: Bristol stool scale.;Digestive problems. Timepoint: Measurement of the Digestive problems after each bowel movement after starting Cassia fistula syrup. Method of measurement: Make a note in the checklist.;Measurement of blood sodium. Timepoint: Measurement of blood sodium before intervention, two weeks after and four weeks after intervention. Method of measurement: blood test.;Measurement of blood potassium. Timepoint: Measurement of blood potassium level before the intervention, two weeks after and four weeks after the intervention. Method of measurement: blood test.;Measurement of blood hemoglobin. Timepoint: Measurement of blood hemoglobin level before the intervention and four weeks after the intervention. Method of measurement: blood test.;Measurement of blood hematocrit. Timepoint: Measurement of blood hematocrit before intervention and four weeks after intervention. Method of measurement: blood test.;Blood platelet count. Timepoint: Measurement of blood platelet count before the intervention and four weeks after the intervention. Met	—

Measure

Time frame

Quality of Life Score in the Patient Assessment of Constipation Quality of Life (PAC-QOL) questionnaire. Timepoint: Measurement of quality of life before the intervention and 30 days after the start of Cassia fistula syrup. Method of measurement: Patient Assessment of Constipation Quality of Life (PAC-QOL) questionnaire.;Constipation score in the Constipation Assessment Scale (CAS). Timepoint: Measurement of Constipation before the intervention and 30 days after the start of Cassia fistula syrup. Method of measurement: Constipation Assessment Scale (CAS).;Frequency and frequency of defecation. Timepoint: Measurement of the frequency of defecation on a daily basis the start of Cassia fistula syrup. Method of measurement: Make a note in the checklist.;Stool consistency in the Bristol stool scale. Timepoint: Measurement of the stool consistency after each bowel movement after starting Cassia fistula syrup. Method of measurement: Bristol stool scale.;Digestive problems. Timepoint: Measurement of the Digestive problems after each bowel movement after starting Cassia fistula syrup. Method of measurement: Make a note in the checklist.;Measurement of blood sodium. Timepoint: Measurement of blood sodium before intervention, two weeks after and four weeks after intervention. Method of measurement: blood test.;Measurement of blood potassium. Timepoint: Measurement of blood potassium level before the intervention, two weeks after and four weeks after the intervention. Method of measurement: blood test.;Measurement of blood hemoglobin. Timepoint: Measurement of blood hemoglobin level before the intervention and four weeks after the intervention. Method of measurement: blood test.;Measurement of blood hematocrit. Timepoint: Measurement of blood hematocrit before intervention and four weeks after intervention. Method of measurement: blood test.;Blood platelet count. Timepoint: Measurement of blood platelet count before the intervention and four weeks after the intervention. Met

—

Secondary

Measure	Time frame
Itching score in the Itchy Quality of Life (ItchyQoL) questionnaire. Timepoint: Measurement of pruritus before the intervention and 30 days after the start of Cassia fistula syrup. Method of measurement: Itchy Quality of Life (ItchyQoL) questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactsadegh shirvanifarsani

Shahed University

sadegh.shirvani1370@gmail.com+98 38 3323 4227

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026