Resistant depression. Major depressive disorder, recurrent, unspecified
Conditions
Interventions
Intervention 1: In the first intervention group: patients are treated with a single dose of ketamine. In this group, ketamine is received only once, 50 cc of normal saline, which contains 0.5 mg per k
Sponsors
Kashan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Males and females, aged 18 -65 years old DSM-V Major Depression Disorder diagnosis confirmed by The Hamilton Depression Rating Scale The patient has refractory depression, a type of major depression that has not responded to traditional treatment options and the first line of treatment and has taken at least 2 trials of antidepressant drug without sufficient response
Exclusion criteria
Exclusion criteria: Having other psychiatric illnesses other than major depression Having a history of one or more seizures for no apparent reason Pregnancy and lactation Bipolar disorder Having uncontrolled non-psychiatric illnesses, including cardiovascular disease Having a history of stimulant use during the last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score based on Hamilton scale. Timepoint: Monthly. Method of measurement: Hamilton questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfshin Ahmadvand
Kashan University of Medical Sciences
Outcome results
None listed