Description of patients with diffuse brain injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: Intervention group: Receiving vitamin C in a dose of 10 g / 100 ml daily as a continuous infusion (4.166 ml / h) for 7 days. Intervention 2: Control group: ormal sa
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: Adult patients aged 16 years or older and <60 years Moderate to severe diffuse axonal injury with a Glasgow coma score of 4 to12 Admission with diagnosis of diffuse brain injury as defined by ICD-10 S06.2 within the first 24 hours of injury Radiological diagnosis of diffuse axonal brain injury
Exclusion criteria
Exclusion criteria: Patients with a specific pathology on a CT scan of the brain that is inconsistent with the diagnosis of DAI Patients with acute and chronic liver injuries Ptients with acute and chronic renal insufficiency and those at high risk for urinary stones. people with underlying conditions such as uncontrolled diabetes, high blood pressure , chronic obstructive pulmonary disease , blood diseases ,Malnutrition or unusual diets. Previous central nervous system injury , concomitant spinal cord injury, space-occupying lesions requiring emergency evacuation Patients whose guardians do not consent to participate in the study patients with a previous diagnosis of severe psychiatric illness or substance abuse patients with shock or hypoxia or Cardiopulmonary arrest following trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute Brain Biomarker S100B Protein. Timepoint: First ,Third and Eighth Day. Method of measurement: ELISA kit S100B. | — |
Secondary
| Measure | Time frame |
|---|---|
| Glasgo Coma Score. Timepoint: The begining of the intervention,Third and Eighth Day. Method of measurement: Glasgo Coma Score Table.;Acute Oxalate Nephropathy. Timepoint: The begining of Study,Third and Eighth day. Method of measurement: Measurement of urinary output,oxalate amount and specific gravity of urine,urea ,uric acid and creatinin of plasma.;Glasgow Outcome Score. Timepoint: The begining of study,first and Third month. Method of measurement: Glasgow Outcome Score Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAnoush Dehnadi Moghadam
Rasht University of Medical Sciences
Outcome results
None listed