Magnesium sulfate as an adjuvant to peribulbar block for glaucoma surgery in morbidly obese patients

Safety and efficacy of magnesium sulfate as an adjuvant to peribulbar block for glaucoma surgery in morbidly obese patients: A randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210118050069N1

Enrollment

Registered

2021-01-27

Start date

2021-02-01

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peribulbar block in adult, morbidly obese patients undergoing glaucoma surgery.. Glaucoma

Interventions

Intervention 1: Intervention group 1 (MS-75): This group will be given peribulbar anesthesia with a local anesthetic mixture composed of 4 ml of lidocaine 2% (Sunny Pharmaceutical, Egypt), 4 ml of bup

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Glaucoma surgery patients ASA physical status I, II, or III Aged from 18 to 70 years Axial length 20-28 mm Body mass index 30-55 kg/m2

Exclusion criteria

Exclusion criteria: Coagulopathy or use of anticoagulant drugs Previous allergy or adverse reaction to the used drugs Patients with conditions preventing them from lying flat or staying still during operation as skeletal problems, orthopneic patients, or those with uncontrolled tremors (as Parkinsonism)

Design outcomes

Primary

Measure	Time frame
The onset of globe akinesia. Timepoint: At 1, 3, and 5 min after the block. Method of measurement: The 3-point scale.;The onset of lid akinesia. Timepoint: At 1, 3, and 5 min after the block. Method of measurement: The 3-point scale.;The intraocular pressure. Timepoint: At baseline, 1, 3, and 5 minutes after local anesthesia. Method of measurement: Schiotz tonometer.	—

Secondary

Measure	Time frame
The duration of analgesia. Timepoint: At 1, 2, and 4 h postoperative. Method of measurement: The Visual Analogue Scale.;The duration of motor block. Timepoint: At 1, 2, and 4 h postoperative. Method of measurement: Clinical assessment of regaining full movement.;Patient satisfaction. Timepoint: Immediately after the block. Method of measurement: Asking the patient.;Surgeon satisfaction. Timepoint: Immediately after the block. Method of measurement: Asking the surgeon.;The vital data (heart rate, oxygen saturation, and non-invasive blood pressure). Timepoint: Every 5 minutes during the operation. Method of measurement: Electronic vital signs monitor.	—

Measure

Time frame

The duration of analgesia. Timepoint: At 1, 2, and 4 h postoperative. Method of measurement: The Visual Analogue Scale.;The duration of motor block. Timepoint: At 1, 2, and 4 h postoperative. Method of measurement: Clinical assessment of regaining full movement.;Patient satisfaction. Timepoint: Immediately after the block. Method of measurement: Asking the patient.;Surgeon satisfaction. Timepoint: Immediately after the block. Method of measurement: Asking the surgeon.;The vital data (heart rate, oxygen saturation, and non-invasive blood pressure). Timepoint: Every 5 minutes during the operation. Method of measurement: Electronic vital signs monitor.

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Countries

Egypt

Contacts

Public ContactDr. Norhan Sherif

Research Institute of Ophthalmology

anesth.sherif@gmail.com+20 2 35718304

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026