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Comparison of the Effects of Dexmedetomidine and Fentanyl-Midazolam Combination on Mitigating Stress Response for Microlaryngoscopy

Comparison of the Effects of Dexmedetomidine and Fentanyl-Midazolam Combination on Mitigating Stress Response for Microlaryngoscopy: A Randomized, Double-Blind, Clinical Trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210117050057N2
Enrollment
60
Registered
2021-03-19
Start date
2021-03-25
Completion date
Unknown
Last updated
2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Microlaryngoscopy. Other diseases of larynx

Interventions

Intervention 1: Dexmedetomidine group: 30 patients who received 1 µg/kg of dexmedetomidine over 10 minutes before anesthesia induction followed by 0.05 mg/kg/h as infusion after anesthesia induction.

Sponsors

Magrabi Eye, ENT and Dental Center, Doha, Qatar
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 18-65 years ASA grade I/III Scheduled for microlaryngoscopy

Exclusion criteria

Exclusion criteria: Patients with known allergy to study drugs Coronary artery disease Pulmonary disease Arrhythmia Pregnancy Renal impairment

Design outcomes

Primary

MeasureTime frame
Hemodynamic stress response. Timepoint: Intraoperative. Method of measurement: Systolic Blood Pressure , Mean Arterial Pressure, Heart Rate were monitored.

Secondary

MeasureTime frame
Intraoperative requirement of propofol. Timepoint: Intraoperative. Method of measurement: Total dose guided by bispectral index.;Sedation. Timepoint: Postoperative. Method of measurement: Ramsay score.;Analgesia. Timepoint: Postoperative. Method of measurement: Visual Analogue Scale.;Anesthesia duration. Timepoint: Intraoperative. Method of measurement: Time measurement.;Recovery time. Timepoint: Postoperative. Method of measurement: Time measurement.

Countries

Qatar

Contacts

Public ContactMOHAMED ORIBY

Faculty of Medicine, Tanta University

oraiby500@hotmail.com+974 3305 9056

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026