Comparison of two different doses of intrathecal ropivacaine in patients undergoing cesarean section

Comparison of two different doses of intrathecal ropivacaine on onset and duration of sensory and motor block in patients undergoing cesarean section with spinal anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210114050036N1

Enrollment

Registered

2021-04-17

Start date

2018-09-23

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Investigation of the onset and duration of sensory and motor blocks in the administration of two different doses of intrathecal ropivacaine.

Interventions

Intervention 1: Intervention group: 30 mg rupivocaine 0.5% made by Molteni company with a volume of 6 cc was injected intrathecally in the L4-L5 space. Intervention 2: Intervention group: 20 mg rupivo

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Term pregnancy ASA Class 1 Candidates for non-emergency cesarean section under the spinal anesthesia

Exclusion criteria

Exclusion criteria: Fetal anomalies Heart, liver, kidney or cerebrovascular diseases Preeclampsia and eclampsia Weighting less than 50 kg or more than 100 kg Sensitivity to any of the drugs used in the study For any reason that the patient needs general anesthesia Patient dissatisfaction for entering to the study

Design outcomes

Primary

Measure	Time frame
Onset and duration of sensory block. Timepoint: Examine the sensory level in first minute and then every 2 minutes to 15 minutes and then every 15 minutes to an hour, then every 10 minutes until the sensory level returns to T10. Method of measurement: Pin-prick test using a 22 Gauge needle.;Onset and duration of motor block. Timepoint: Investigation of the motor block in first minute and then every 2 minutes to 15 minutes and then every 15 minutes to an hour, then every 10 minutes until motor block return to a scale lower than the maximum movement block created. Method of measurement: Modified Bromage scale.	—

Measure

Time frame

Onset and duration of sensory block. Timepoint: Examine the sensory level in first minute and then every 2 minutes to 15 minutes and then every 15 minutes to an hour, then every 10 minutes until the sensory level returns to T10. Method of measurement: Pin-prick test using a 22 Gauge needle.;Onset and duration of motor block. Timepoint: Investigation of the motor block in first minute and then every 2 minutes to 15 minutes and then every 15 minutes to an hour, then every 10 minutes until motor block return to a scale lower than the maximum movement block created. Method of measurement: Modified Bromage scale.

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Secondary

Measure	Time frame
Systolic, diastolic and mean arterial pressure. Timepoint: At the beginning of study (before the intervention) and then every 3 minutes until the baby was born and then every 5 minutes until the end of surgery. Method of measurement: Non-invasive blood pressure monitoring.;Heart rate. Timepoint: Continuously from the beginning of the study (before the intervention) until the end of surgery. Method of measurement: Electrocardiogram monitoring.	—

Measure

Time frame

Systolic, diastolic and mean arterial pressure. Timepoint: At the beginning of study (before the intervention) and then every 3 minutes until the baby was born and then every 5 minutes until the end of surgery. Method of measurement: Non-invasive blood pressure monitoring.;Heart rate. Timepoint: Continuously from the beginning of the study (before the intervention) until the end of surgery. Method of measurement: Electrocardiogram monitoring.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMojdeh Niknafs

Yazd University of Medical Sciences

mh.yavari@shahed.ac.ir+98 35 3725 8222

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026