Skip to content

??Effect of Hypericum Perforatum extract on tissue healing.

Evaluation of effect of Hypericum Perforatum extract on soft tissue healing of tooth extraction socket.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210113050025N1
Enrollment
30
Registered
2021-01-21
Start date
2021-01-30
Completion date
Unknown
Last updated
2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postextraction socket healing.

Interventions

Intervention 1: Intervention group: After achieving adequate anesthesia and tooth extraction the dentist will place 2ml of 5% gel containing Hypericum Perforatum extract with the use of a syringe in

Sponsors

Sanandaj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: People 18 to 30 years old bilateral maxillary premolars extraction for orthodontic reasons

Exclusion criteria

Exclusion criteria: Pregnancy Breastfeeding Traumatic and surgical extractions History of systemic diseases and allergies Smoking Alcohol abuse History of taking corticosteroids, contraceptives and antidepressants Need to take antibiotics and NSAIDs after tooth extractions Periodontal disease, infection or any pathology at the area of the tooth indicated for extraction Need more than one carpule to create local anesthesia Who are not willing to participate during the follow ups

Design outcomes

Primary

MeasureTime frame
Healing score. Timepoint: Third and seventh day after tooth extraction. Method of measurement: Healing index by Landry, Turnbull and Howley.;Wound size. Timepoint: Extraction day (baseline), third and seventh day after tooth extraction. Method of measurement: Castroviejo caliper.

Secondary

MeasureTime frame
Pain severity. Timepoint: Extraction day (baseline), third and seventh day after tooth extraction. Method of measurement: Numeric Pain Rating Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Haghighatpasand Astaneh

Sanandaj University of Medical Sciences

sogand.haqiqat76@gmail.com+98 87 3366 4648

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026