Ulcerative colitis. Ulcerative colitis
Conditions
Interventions
Intervention group: 5 patients with ulcerative colitis and 5 healthy donors according to inclusion and exclusion criteria using non-probable method will enter into the study. The fresh stool samples w
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: For the patients: the volunteers aged 18-65 years with Ulcerative Colitis who have been diagnosed by 3 months and are in moderate-severe phase For the stool donor: the healthy volunteers aged 18-65 years
Exclusion criteria
Exclusion criteria: For the stool donor: Having signs or existence of gastro- enteric diseases existence of other diseases like diabetes, cardiovascular, liver, and kidney diseases Using antibiotic/ anti fungal/ anti viral or probiotics Using immunosuppressive and anti carcinogenic drugs affected by autoimmune and atopic diseases With metabolic syndrome, obesity(BMI>30) or under nutrition(BMI<18) chronic pain syndrome, psychological diseases, and carcinoma Infectious disease like hepatitis B, hepatitis C, AIDS, and respiratory infections Close contact to somebody who have had viral hepatitis or AIDS during the last year high risk behaviors like sigh risky sex, tattooing, or piercing in the last 6 months consumption illegal drugs and opium going to diarrheic endemic zone during the last 6 months the history of inflammation bowel diseases, chronic diarrhea and the other GI diseases the history of GI cancer or Polyposis the history of colorectal cancer in the first degree relatives the history of GI surgery like bypass infected by corona virus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The clinical score based on Lightiger test. Timepoint: at the first(mo 0), after intervention period(mo 2), at the end(mo 4). Method of measurement: using Lightiger questionnaire.;Quantity of intestinal targeted bacteria. Timepoint: at the first(mo 0), and at the end(mo 4) of study. Method of measurement: Q-PCR. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNazila Kassaian
Esfahan University of Medical Sciences
Outcome results
None listed