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The effect of probiotics on salivary pH and flow rate

: The effect of probiotics on salivary pH and flow rate in healthy subjects, A double blinded, randomized, controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210112050013N1
Enrollment
60
Registered
2021-03-02
Start date
2021-03-16
Completion date
Unknown
Last updated
2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Saliva flow rate. Condition 2: Saliva pH.

Interventions

Intervention 1: In the intervention group, lactogam probiotic lozenges containing Streptococcus salivarius K12 and Streptococcus salivarius M18, (CFU <109) with natural mint flavor and without sugar,

Sponsors

Bojnourd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Healthy people aged 20 to 40 who fill out an informed consent form

Exclusion criteria

Exclusion criteria: Presence of a marked systemic disease History of smoking and alcohol consumption Pregnancy and lactation status Patients with complete edentulousness There are specific symptoms of dry mouth, including fissure lip and palate, rampant caries, fungal infections, adhesions of the tongue and mucous membranes to the teeth, etc History of consumption of other products containing probiotics in the past month History of taking any medication, including antibiotics, antiseptics, Saliva reducing or increasing drugs in the past month

Design outcomes

Primary

MeasureTime frame
Number of digital scales. Timepoint: Measurement of salivary flow rate at the beginning of the study (before the intervention), one and two months after the start of probiotic use. Method of measurement: Digital scale device.;Number digital pH meter. Timepoint: Measurement of saliva pH at the beginning of the study (before the intervention), one and two months after the start of probiotic use. Method of measurement: Digital pH meter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJavid Rasekhi

Bojnourd University of Medical Sciences

zohrehamiri23@yahoo.com+98 58 3228 9322

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026