Evaluation of the effect of caffeine on separation from ventilators of patients admitted to the intensive care unit

Evaluation of the effect of oral caffeine in helping to liberate (Liberation) from the ventilator in intubated and mechanically ventilated patients admitted to the intensive care unit

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210110049990N2

Enrollment

124

Registered

2021-12-23

Start date

2022-03-21

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intubated and mechanically ventilated patients admitted to the intensive care unit.

Interventions

Intervention 1: Intervention group: Patients receive caffeine tablets at a dose of 200 mg twice daily through the gastric tube. Intervention 2: Control group: Patients receive a placebo at a dose of 2

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All intubated patients in the General ICU are expected to be ventilator-dependent for more than 48 hours.

Exclusion criteria

Exclusion criteria: Myopathy Ischemic heart problems Cardiac arrhythmia Neurosurgery patients Caffeine sensitivity

Design outcomes

Primary

Measure	Time frame
APACHEII. Timepoint: The beginning of the study and 7 days later. Method of measurement: APACHEII form and laboratory information.;Rapid Shallow Breathing Index. Timepoint: The beginning of the study and 7 days later. Method of measurement: Respiratory rate divided by respiratory volume.	—

Secondary

Measure	Time frame
Duration of mechanical ventilation. Timepoint: The beginning of the study and 7 days later. Method of measurement: Review of the patient's clinical record.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Poujea Shojaei

Shahid Beheshti University of Medical Sciences

P.Shojaei@sbmu.ac.ir+98 21 7343 2000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026