Evaluation of the effect of melatonin on colistin nephrotoxicity

Evaluating the effect of oral melatonin in colistin induced nephrotoxicity in the intensive care unit

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210110049990N1

Enrollment

Registered

2021-03-01

Start date

2021-03-21

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nephrotoxicity. Acute kidney failure, unspecified

Interventions

Intervention 1: Intervention group: Patients receive a treatment protocol approved by the Ministry of Health during their hospital stay. Patients in the intensive care unit treated with colistin will

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: All patients that admitted to the intensive care unit who are being treated with Colistin

Exclusion criteria

Exclusion criteria: Patient or legal counsel dissatisfaction People under 18 years old People with impaired kidney function and creatinine levels greater than 1.5 mg / dL

Design outcomes

Primary

Measure	Time frame
24-hour urine volume. Timepoint: Ten days. Method of measurement: Container for measuring the volume of liquids.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPoujea Shojaei

Shahid Beheshti University of Medical Sciences

mohammadtorabi628@yahoo.com+98 21 7343 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026