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using combination of Celecoxib and Escitalopram for the treatment of depression

The effect of adding Celecoxib to Escitalopram in the treatment of symptoms of Major Depressive Disorder

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210109049979N1
Enrollment
70
Registered
2021-02-01
Start date
2021-04-04
Completion date
Unknown
Last updated
2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder. Major Depressive Disorder

Interventions

Intervention 1: Intervention group: Recipient of 10 mg oral Escitalopram made by Sobhan Pharmaceutical Company (Lextal) as a single daily dose and 400 mg oral Celecoxib made by Tehran Pharmaceutical C

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Having major depressive disorder Range age betweenh 15-55 years Agree to participate in the study

Exclusion criteria

Exclusion criteria: Existence of another psychiatric disorder Presence of heart disease or the presence of serious risk factors for heart disease Presence of renal impairment Antidepressant treatment in the last 6 months Physical disorders that lead to depression (such as hypothyroidism). Pregnancy Drug addiction major depression Perform parallel treatments Withdrawal from continuing to participate in the study

Design outcomes

Primary

MeasureTime frame
Severity of major depressive disorder. Timepoint: Before the intervention, 4 weeks and 8 weeks after the intervention. Method of measurement: Hamilton Depression questionnaire.

Secondary

MeasureTime frame
Treatment side effect. Timepoint: Every month. Method of measurement: Hamilton Depression questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Mosadegh

Yazd University of Medical Sciences

maryammosadegh306@gmail.com+98 31 3356 3466

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026