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Comparative Study of The Effect of Botanical Extract Mouthwashes of Tea Tree Oil/Aloe vera and Chlorhexidine on Prevention of Ventilator-Associated Pneumonia in Admitted Patients in Intensive Care Unites

Comparative Study of The Effect of Botanical Extract Mouthwashes of Tea Tree Oil/Aloe vera and Chlorhexidine on Prevention of Ventilator-Associated Pneumonia in Admitted Patients in Intensive Care Unites

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210104049936N1
Enrollment
62
Registered
2022-08-14
Start date
2022-08-16
Completion date
Unknown
Last updated
2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-Associated Pneumonia. Ventilator associated pneumonia

Interventions

Intervention 1: Intervention group: Before performing oral care, hands are washed according to the instructions and gloves are worn, and the oral cavity is evaluated. If there is a lesion, the doctor

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 65 Years

Inclusion criteria

Inclusion criteria: To have oral endotracheal tube Age between 16 to 65 Being at least 72 hours ventilated Absence of pulmonary infection based on the modified pulmonary infection clinical score (score less than 5 at the time of study entry) Absence of history of allergy to herbal compounds of tea tree oil or aloe vera (based on the history obtained from the legal guardian or the patient's companion) Absence of specific oral lesions or infections Absence of sepsis, pulmonary thromboembolism, absence of history and signs of aspiration, absence of orthodontics, atelectasis, inflammatory gastrointestinal or bile ducts diseases and severe liver diseases according to the diagnosis of a specialist doctor (based on physical examination and history obtained from the legal guardian or with the patient).

Exclusion criteria

Exclusion criteria: Traumatization during intubation Transferring patient from the ICU (for any reason) or death before completing the study Patient extubation for any reason Withdrawal or unwillingness of the legal guardian of the patient to continue the study Observing side effects caused by using mouthwash such as hives, itching and skin rashes Sudden changes in the patient's clinical condition or breathing pattern The presence of defects in the patient's immune system

Design outcomes

Primary

MeasureTime frame
Ventilator-Associated Pneumonia. Timepoint: Assessing the presence or absence of ventilator-associated pneumonia upon entering the study (before the start of the intervention), day 3 (to diagnose early ventilator-associated pneumonia) and day 7 (to diagnose late ventilator-associated pneumonia) after the intervention. Method of measurement: The diagnosis of ventilator-associated pneumonia in this research will be done using the Modified Clinical Pulmonary Infection Score (MCPIS). This tool includes five laboratory and a score of 0-2 is considered for each criterion and the maximum score is 10. If the sum of scores is equal to or more than 6, pneumonia is diagnosed.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParisa Mohseni

Shahid Beheshti University of Medical Sciences

parisamohseni074@gmail.com00988633670287, 00988632268807

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026