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The effect of vitamin A supplementation in outpatients with COVID-19

Comparing the effect of standard treatment with and without vitamin A supplementation in improving the clinical symptoms of outpatients with COVID-19

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210102049912N1
Enrollment
140
Registered
2021-04-07
Start date
2021-04-09
Completion date
Unknown
Last updated
2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19, virus identified

Interventions

Intervention 1: Intervention group: In the intervention group, in addition to receiving the national standard treatment, patients will receive oral vitamin A 25,000 international units (Zahravi-Iran)

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 75 Years

Inclusion criteria

Inclusion criteria: Having clinical signs and test results that confirm COVID-19 CRP level higher than 0.3 mg per liter Having an ESR higher than 22 mm per hour for women and 29 mm per hour for men

Exclusion criteria

Exclusion criteria: Having any autoimmune disease (lupus, MS, etc.) Suffering from diseases that interfere with the absorption of vitamin A. Consumers of vitamin A supplements Patients with severe renal insufficiency and dialysis Patients with underlying liver disease Pregnancy Lactation

Design outcomes

Primary

MeasureTime frame
Clinical symptoms improvement. Timepoint: Before the intervention and 10 days after the start of the intervention. Method of measurement: Definition of clinical improvement includes normalization of body temperature (=37.2's,) number of breaths (= 24 breaths per minute,) oxygen saturation (> 94% at room temperature) that is stable for at least 24 hours.;Hospitalization. Timepoint: Ten days after the start of the intervention. Method of measurement: Patients' hospitalization will be recorded using a questionnaire and their follow-up.;C-reactive protein. Timepoint: Before the intervention and 10 days after the intervention. Method of measurement: Hemagglutination.;Erythrocyte Sedimentation Rate. Timepoint: Before the intervention and 10 days after the intervention. Method of measurement: Erythrocyte Sedimentation test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Shokri

Arak University of Medical Sciences

dr_mehdi75@yahoo.com+98 86 3417 3630

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026