Hypothyroidy. Ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere
Conditions
Interventions
Intervention 1: Intervention group: They receive levothyroxine and herbal composition (nigella sativa, trachyspermum ammi, citrus aurantifolia) at a dose of 4.5 g daily in 6 capsules of 750 mg for 8 w
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age: 20 to 65 years Patients known to have primary hypothyroidism by an endocrinologist Hypothyroid patients with overweight or obesity whose weight has not been controlled with levothyroxine
Exclusion criteria
Exclusion criteria: Uncontrolled systemic diseases Any diet for weight loss during the study and 3 months before arrival Take a vitamin supplement at least three months before or during the study Patient dissatisfaction with continued cooperation Pregnancy Lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: Before and after intervention. Method of measurement: To measure weight, calculate the ratio of weight in kilograms to height squared in meters (body mass index) and calculate the ratio of waist to hip in centimeters (WHR) using weight and tape meters. | — |
Secondary
| Measure | Time frame |
|---|---|
| Lipid profile. Timepoint: Before and after intervention. Method of measurement: By blood test in mg/dl.;Fasting blood sugar. Timepoint: Before and after intervention. Method of measurement: By blood test in mg/dl.;Thyroid hormone (TSH, FT4, T3). Timepoint: Before and after intervention. Method of measurement: By blood test in ng/dl.;Depression score on Beck Depression questionnaire. Timepoint: Before and after intervention. Method of measurement: Beck Depression questionnaire.;Quality of Life score on WHO Quality of Life Questionnaire. Timepoint: Before and after intervention. Method of measurement: WHO Quality of Life Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNajme Javidi
Mashhad University of Medical Sciences
Outcome results
None listed