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Effect of Clcitriol in Ischemi stroke

Comparison between calcitriol and placebo on serum interleukin 6 level, stroke severity, infarct volume and clinical outcomes in patients with ischemic stroke

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210101049905N2
Enrollment
78
Registered
2021-11-22
Start date
2021-11-11
Completion date
Unknown
Last updated
2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Stroke. Cerebral infarction due to thrombosis of unspecified precerebral artery

Interventions

Intervention 1: Intervention group: In this group, in addition to the standard treatment, Dana Company's oral calcitriol is prescribed to patients at the dose of 1 microgram once a day for 5 days. Int

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Age 18 to 85 years Focal neurological disorder Clinical diagnosis of acute ischemic stroke Radiological findings of MRI and CT are consistent with the clinical diagnosis of acute hemisphere stroke Patients who have been hospitalized for the first 24 hours after a stroke. Patients suffering from ischemic stroke for the first time

Exclusion criteria

Exclusion criteria: Evidence based on acute or chronic intracerebral hemorrhage and cerebral aneurysm Existence of any etiology other than ischemia Existence of any cognitive or behavioral disorders that lead to the patient not cooperating. Consumption of any combination or drug with antioxidant effects except prescription drugs Existence of another concomitant inflammatory disease Taking medications other than standard ischemic stroke treatments that alter the levels of the factors under consideration. Pregnancy and lactation Use any combination with antioxidant and anti-inflammatory effects in the past month Asthma and a history of anaphylactic shock Taking drugs that interfere with calcitriol

Design outcomes

Primary

MeasureTime frame
Interleukin 6. Timepoint: At the beginning of the study and 3 days after the end of the medication. Method of measurement: ELISA test.;National Institutes of Health Stroke Scale score. Timepoint: At the beginning of the study and 90 days after the end of the medication. Method of measurement: NIHSS questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdi Mahanpoor

Hamedan University of Medical Sciences

mahdymahanpoor@yahoo.com+98 86 3224 2129

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026